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  • Though there may be similarities between SARS-CoV-2 and influenza, there are also meaningful differences. The most obvious difference is the efficacy of SARS-CoV-2 vaccines, which is currently much higher than we can achieve with influenza vaccines. Whether that degree of efficacy will continue is one of the many open questions that can only be answered over time. It is clear, however, that revaccination will be necessary, for the same reasons that influenza revaccination is necessary: antigenic variation and waning immunity. Data on the frequency of reinfection with seasonal coronaviruses may not be relevant, but they suggest that protection is relatively short term even after natural infection.5 Revaccination frequency and consequences will need to be determined.

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