Protection offered by booster shot beats ‘natural immunity,’ study suggests latimes.com
In people who got a booster shot, levels of neutralizing antibodies exceeded the peak that followed two doses of COVID-19 vaccine.
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Two-dose messenger RNA vaccines (BNT162b2/Pfizer and mRNA-1273/Moderna) against
SARS-CoV-2 were rolled out in the US in December 2020, and provide protection against
hospitalization and death from COVID-19 for at least six months. Breakthrough infections have
increased with waning immunity and the spread of the B.1.617.2 (Delta) variant in summer
2021, prompting approval of boosters for all adults over 18. We measured anti-receptor binding
domain (RBD) IgG and surrogate virus neutralization of the interaction between SARS-CoV-2
spike protein and the human angiotensin-converting enzyme (ACE2) receptor, before and after
boosters in N=33 healthy adults. We document large antibody responses 6-10 days after
booster, with antibody levels that exceed levels documented after natural infection with COVID19, after two doses of vaccine, or after both natural infection and vaccination. Surrogate
neutralization of B.1.617.2 is high but reduced in comparison with wild-type SARS-CoV-2.
These data support the use of boosters to prevent breakthrough infections and suggest that
antibody-mediated immunity may last longer than after the second vaccine dose.
https://www.medrxiv.org/content/10.1101/2021.11.19.21266555v1.full.pdf